Examining the role of human dendritic cells in mediating sexual transmission of HIV

【Author】

Andrew Harman;

【Abstract】

<正>Anogenital dendritic cells(DC)are amongst the first cells to encounter HIV during sexual intercourse.They play a crucial role in transmission as they efficiently transfer the virus to CD4 T cells in which HIV explosively replicates.Firstly,an early phase of transfer occurs which is dependent on C-type lectin receptor mediated HIV uptake by DCs and rapidly declines with time.Later a second phase occurs which increases

【Keywords】

sexual;amongst;lectin;uptake;dermal;encounter;Langerhans;lamina;infected;inflammation;

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