Dendritic cell subsets in the control of visceral adipose tissue homeostasis

【Author】

Sandeep Sundara-Rajan;Elizabeth Wood;Jakob Loschko;Valeria Scagliotti;Fearon Cassidy;Carles Gaston-Massuet;Marika Charalambous;Michel Nussenzweig;M.Paula Longhi;

【Abstract】

<正>Obesity is associated with chronic low-grade inflammation in visceral adipose tissue(VAT),which is now established as an important driving factor for metabolic diseases.In this context,maintenance of a local suppressive immune-microenvironment is essential for the control of VAT normal function and metabolic homeostasis.Classical Dendritic cells(c DCs)are the main antigen presenting cells linking innate and adaptive immune responses,however,their study in VAT has been hampered

【Keywords】

visceral;adipose;homeostasis;maintenance;innate;inflammation;linking;driving;PPAR;finger;

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