Oxidized mitochondrial DNA is a powerful activator of human pDCs and induces a lupus-specific CD4 T cell phenotype

【Author】

Simone Caielli;Bojana Domic;Elise Murat;Chandra Manjari;Romain Banchereau;Zhaohui Xu;Jacques Banchereau;Virginia Pascual;

【Abstract】

<正>Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by breakdown of tolerance to nuclear antigens,immune complex(IC)deposition in tissues and multiorgan involvement.The skin,blood vessels,kidneys,central nervous system,and joints become targets of inflammation at onset or during the course of the disease.Genomic approaches have shown that>95%of children with SLE display two peculiar blood signatures,namely type I IFN-and neutrophil-related.Indeed,

【Keywords】

erythematosus;phenotype;autoimmune;powerful;peculiar;neutrophil;breakdown;inflammation;involvement;joints;

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