Homeostatic DC signatures limit anti-tumor immunity


Christopher Nirschl;Yong Liu;Tae-gyun Kim;Ruth Dannenfelser;Qian Zhu;Melika Rezaee;David Chau;Kavita Sarin;Nicholas Gulati;George Song-Zhao;Judilyn Fuentes-Duculan;James Krueger;Olga Troyanskaya;Mayte Suarez-Farinas;Niroshana Anandasabapathy;


<正>Dendritic cells(DC)are gatekeepers of immunity,critical to both initiate an immune response upon infection and promote tolerance to self-antigens.In vivo however it remains poorly understood how some DCs will generate tolerance,while others conduct immune priming under the same conditions.We recently established that DC subsets in peripheral tissues such as skin that constitutively migrate into LNs,individually and collectively temper an on-going immune response during protein




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