Ontogeny of inflammatory macrophages and monocyte-derived dendritic cells

【Author】

Pierre Guermonprez;

【Abstract】

<正>Inflammation triggers the recruitment and differentiation of inflammatory monocytes into microbicidal macrophages or monocyte-derived dendritic cells(mo DCs).It is unclear if environmental inflammatory cues control the polarization of monocytes toward each of these fates or if specialized monocyte progenitor subsets exist prior to inflammation.Here we show that na?ve monocytes are heterogeneous and contain a NR4A1-and Flt3L-independent,CCR2-dependent,

【Keywords】

macrophages;monocyte;specialized;progenitor;prior;inflammation;heterogeneous;unclear;toward;distal;

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