RUNX2 mediates plasmacytoid dendritic cell egress from the bone marrow and controls viral immunity

【Author】

Michael Chopin;Simon Preston;Aaron Lun;Julie Tellier;Gordon Smyth;Gabrielle Belz;Marc Pellegrini;Jane Visvader;Lynn Corcoran;Li Wu;Stephen Nutt;

【Abstract】

<正>Dendritic cells(DCs)have evolved into a diverse family of cellular subsets,each with their own distinctive features.Plasmacytoid DCs(p DCs)represent a unique immune cell type that responds to viral nucleic acids through the rapid production of type I interferons.Within the hematopoietic system,the transcription factor RUNX2 is exclusively expressed in p DCs and is required for their peripheral homeostasis.Here

【Keywords】

immunity;egress;homeostasis;hematopoietic;diverse;evolved;exclusively;distinctive;nucleic;integrin;

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