TopBP1 is essential for the development of dendritic cells and DC-mediated mucosal homeostasis

【Author】

Min-Suk Cha;

【Abstract】

<正>Topoisomerase II-binding protein 1(Top BP1)is essential for DNA repair and DNA replication.Top BP1 plays an important role in the rescue of stalled replication forks and checkpoint control through binding to the double-or single-stranded DNA breaks.Top BP1 is also required for V(D)J rearrangement during the development of B,T and i NKT cells.However,Top BP1 has not yet been reported in association with dendritic cells.In the present study,we found that Top BP1 plays a crucial role in the

【Keywords】

checkpoint;homeostasis;replication;DNA;breaks;repair;mucosal;rearrangement;stranded;impaired;

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