Mapping human dendritic cell development trajectory in healthy donors and patients with myeloid neoplasm using quantitative clonal analysis

【Author】

Yu Jerry Zhou;Jaeyop Lee;Arafat Aljoufi;Wenji Ma;Matthew Thomsen;Prakash Satwani;Govind Bhagat;Yufeng Shen;Kang Liu;

【Abstract】

<正>To establish a coherent model of dendritic cells(DC)development,we recently devised an approach to map development tracks using quantitative clonal analysis of CD34+human hematopoietic stem and progenitor cells(HSPCs).Here we applied this approach to compare DC development in bone marrow(BM)of healthy donors and patients with myeloid neoplasm(including AML,MDS,and MPN),a cohort with prevalent reduction in their DCs and DC-restrict progenitors.To differentiate the

【Keywords】

neoplasm;myeloid;clonal;progenitor;coherent;hematopoietic;Mapping;trajectory;differentiate;prevalent;

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