Genetic dissection of human dendritic cell differentiation

【Author】

Urszula Cytlak;Kile Green;Rachel E Dickinson;Paul Milne;Sinisa Savic;Sophie Hambleton;Matthew Collin;Venetia Bigley;

【Abstract】

<正>Studies in mouse have shown that the functional distinction between DC subsets is linked to ontogeny,regulated by specific genes,but human DC development is less well understood.Humans with DC deficiency afford a unique opportunity to study the genetic control and cellular pathway of DC differentiation.To exploit this we have undertaken 1.In vivo studies of patients with bi-or mono-allelic IRF8 mutations or GATA2 mutation;2.In vitro culture of progenitors

【Keywords】

dissection;opportunity;understood;afford;exploit;mutation;verified;lymphoid;potent;restricted;

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