Human dendritic cells(DCs) are derived from two distinct circulating precursors that are pre-committed to become CD1c+ or CD141+ DCs

【Author】

Gaelle Breton;Shiwei Zheng;Renan Valieris;Israel Tojal da Silva;Rahul Satija;Michel C.Nussenzweig;

【Abstract】

<正>Human blood conventional dendritic cells(c DCs)can be subdivided into CD1c~+and CD141~+populations that display unique specialized functions.Although we know a great deal about how these subsets shape immune responses,much less is known about the origin of c DC lineages diversification.c DCs arise from increasingly restricted but well-defined bone marrow(BM)progenitors that include the

【Keywords】

committed;restricted;specialized;circulating;populations;subdivided;arise;distinguished;progenitor;administration;

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