Treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients with Dexamethasone and MPLA induces a regulatory transcriptional profile overcoming disease-associated effects on gene expression

【Author】

Paulina García-González;Katina Schinnerling;Alejandro Sepúlveda G;Gabriela Ubilla-Olguín;Lilian Soto;Oscar Neira;Ahmed M.Medhi;Hendrik J.Nel;Diego Catalán;Ranjeny Thomas;Ricardo A.Verdugo;Juan Carlos Aguillón;

【Abstract】

<正>Background:Despite the potential of tolerogenic dendritic cells(tol DCs)as cellular therapy in autoimmunity,the mechanisms underlying differentiation towards a regulatory phenotype are poorly understood.We studied the transcriptional profile of tol DCs from healthy controls(HC)and rheumatoid arthritis patients(RA),modulated with dexamethasone(Dex)and monophosphoryl lipid A(MPLA)

【Keywords】

phenotype;modulated;understood;poorly;monocyte;dexamethasone;lipid;underlying;transcripts;profiling;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 0 articles

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 0 articles