The non-canonical Wnt pathway negatively regulates the differentiation of dendritic cell by inhibiting the expansion of Flt3+ lymphocyte-primed multipotent precursors

【Author】

Jing Xiao;Haibo Zhou;Ning Wu;Li Wu;

【Abstract】

<正>The differentiation of dendritic cells(DC)altered during the process of aging.However,the molecular mechanisms for the alteration of DC development in aged mice are far from clarified.Recently,Wnt5a has been reported as an important aging related molecule in hematopoietic system.Here,we suggest that the increased expression of Wnt5a in aged hematopoietic precursors led to deficient differentiation of DC in aged mice.Compared with young mice,the percentages and

【Keywords】

hematopoietic;lymphocyte;clarified;altered;inhibiting;alteration;young;negatively;canonical;deficient;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 0 articles

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 0 articles