Mechanisms of transcription factor Batf2 regulating CD103(+)CD11b(+) dendritic cell development in Toxoplasma gondii infection induced intestinal inflammation

【Author】

Wei Zhou;Mei-Xiang Wang;Zheng-Tao Chen;Hua Tang;

【Abstract】

<正>Dendritic cell(DC)is a heterogeneous group,which plays a central role in regulation of immune response.Batf3,a member of the BATF family of transcription factors,regulates intestinal CD103+DC development under steady-state,while IRF4 is required for homeostatic development of CD103+CD11b+DC.The development and regulatory properties of intestinal DC subsets during infectious state is not clear.Recently studies have shown that Batf2 can direct the compensatory CD103+DC

【Keywords】

Toxoplasma;inflammation;regulating;infectious;heterogeneous;distinguished;targeted;

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