Platelet-activating factor mediates endotoxin tolerance by regulating indoleamine 2,3-dioxygenase-dependent expression of the suppressor of cytokine signaling 3

【Author】

Seung Jun Lee;Kyung Tae Noh;Gun Young Yoon;Da Rae Kang;Hee Jo Park;Yeong-Min Park;In Duk Jung;

【Abstract】

<正>Indoleamine 2,3-dioxygenase(IDO)mediates immune tolerance,and suppressor of cytokine signaling 3(SOCS3)negatively regulates the JAK/STAT signal transduction pathway.We previously determined platelet-activating factor(PAF)protects mice against lipopolysaccharide(LPS)-induced endotoxic shock,but its detailed mechanism of action was unknown.We performed survival experiments in IDO+/+

【Keywords】

activating;cytokine;dioxygenase;suppressor;endotoxin;signaling;regulating;SOCS;negatively;interleukin;

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