Dendritic cell-derived I-32α-a novel inhibitory cytokine of NK cell function

【Author】

Laurent Gorvel;Daniel Korenfeld;Thomas Tung;Eynav Klechevsky;

【Abstract】

<正>Cytokines produced by DCs can largely determine the direction of immunity.Transcriptional analysis revealed that besides IL-15,IL-32 was the only other cytokine expressed by human Langerhans Cells.IL-32 is a human cytokine which exists in four main isoforms.Little is known about the regulation and function of the various IL-32 isoforms.Here we found that IL-15 is a potent inducer of IL-32αin DCs.

【Keywords】

cytokine;Langerhans;immunity;inducer;potent;largely;besides;effector;suppress;regulating;

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