Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression

【Author】

Chaofeng Han;Xiang Hu;Xuetao Cao;

【Abstract】

<正>Interleukin-10(IL-10)plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease(IBD).We previously reported that CD11bhi regulatory dendritic cells(DCs)can produce more IL-10,andCD11b can negatively regulate TLRs-induced inflammatory responses in macrophages.However whether CD11b and its signaling can control autoimmunity

【Keywords】

Integrin;homeostasis;macrophages;Interleukin;negatively;regulate;prevention;mucosal;strengthening;signaling;

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