Rab43 facilitates cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells

【Author】

Derek Theisen;Nicole Kretzer;Roxane Tussiwand;Carlos Brise?o;Gary Grajales-Reyes;Xiaodi Wu;Vivek Durai;J?rn Albring;Prachi Bagadia;Theresa Murphy;Kenneth Murphy;

【Abstract】

<正>Cross-presentation is mediated by Batf3-dependent CD8a+classical dendritic cells(c DCs)in vivo.Many of the vesicular transport molecules involved in cross-presentation by c DCs have not yet been identified.Using gene expression analysis,we identified RAB43,a GTPase that is selectively expressed in CD8a+c DCs.Mice deficient in Rab43 have a defect in cross-presentation of

【Keywords】

presentation;vesicular;GTPase;deficient;regulating;normally;monocyte;lacking;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 0 articles

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 0 articles