Drink and die - a genome-wide CRISPR screen for macropinocytosis regulators

【Author】

Mirjana Weimershaus;

【Abstract】

<正>In the absence of inflammation,DCs use endocytosis,phagocytosis and macropinocytosis to constantly sample their environment which allows them to detect potentially dangerous agents.Macropinocytosis is the major uptake mechanism for extracellular material in immature DCs for subsequent antigen presentation,but is shut-down during maturation.Regulation of macropinocytosis involves Cdc42,Rac1,Rho A,PI3K and actin but the details remain elusive.Here,we

【Keywords】

constantly;elusive;dangerous;maturation;subsequent;details;potentially;presentation;inflammation;uptake;

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