The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

【Author】

Yuanyuan Ding;Zhenhong Guo;Yiqi Liu;Xia Li;Qian Zhang;Xiongfei Xu;Yan Gu;Yi Zhang;Dezhi Zhao;Xuetao Cao;

【Abstract】

<正>CD8+dendritic cells(DCs)are specialized at cross-presenting extracellular antigens on major histocompatibility complex(MHC)class I molecules to initiate cytotoxic T lymphocyte(CTL)responses;however,details of the mechanisms that regulatecross-presentation remain unknown.We found lower expression of the lectin family member Siglec-G in CD8+DCs,and Siglec-G deficient(Siglecg-/-)mice generated more antigen-specific CTLs to inhibit intracellular bacterial infection and tumor

【Keywords】

lectin;presentation;specialized;lymphocyte;cytotoxic;inhibit;initiate;details;intracellular;deficient;

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