IDO-orchestrated crosstalk between pDCs and Tregs controls CNS autoimmunity

【Author】

Carla Lippens;

【Abstract】

<正>Plasmacytoid dendritic cells(p DCs)have been shown to both mediate and prevent autoimmunity,and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood.We have previously described that in absence of antigen presentation by p DCs during Experimental Autoimmune Encephalomyelitis(EAE),a model for multiple sclerosis(MS),regulatory T cell(Treg)development was impaired and disease was severely exacerbated.The present

【Keywords】

crosstalk;impaired;understood;presentation;versus;severely;absence;inhibit;predominant;pointing;

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