Cholera toxin mediates c AMP-dependent CTLA-2 secretion by dendritic cells to induce regulatory T cells

【Author】

Cinthia Solva Vilches;Katrien Pletinckx;Miriam Lohnert;Vladimir Pavlovic;Susanne Kneitz;Jie Zhou;Rena Chen;Thomas Reinheckel;Thomas D.Mueller;Jochen Bodem;Manfred B.Lutz;

【Abstract】

<正>Immature or semi-mature dendritic cells(DCs)represent tolerogenic stages that can convert na?ve T cells into Fox P3+induced regulatory T cells(i Treg).Here we found that murine bone marrow-derived DCs(BM-DCs)matured with cholera toxin(CT)produced cytotoxic T lymphocyte antigen 2(CTLA-2)via c AMP signaling.High or low dose CT(CThi,CTlo)or c AMP treatment of BM-DCs induced m RNA of both isoforms

【Keywords】

secretion;lymphocyte;cholera;mature;cytotoxic;signaling;convert;RNA;murine;autoimmune;

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