CD103+CD11b+ dendritic cells control IL-17 producing γ/δ T cells in the colon

【Author】

Christiane Ruedl;Jianpeng Sheng;Rashid Muzaki;

【Abstract】

<正>Intestinal IL-17 producing g/d T(g/d T17)cells,defined as SCART-2~+Vg4~+CCR6~+g/d T cells,are crucial for a protective innate intestinal immune response.Currently the mechanisms regulating their function in the intestine are still elusive.Here we show that g/d T17 cells are restricted to the colon,they are self-renewing,co-localize with CD103~+CD11b~+dendritic cells(DCs)in innate lymphoid follicles and are functionally

【Keywords】

producing;colon;CD103+CD11b;innate;restricted;functionally;intestine;elusive;protective;regulating;

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