Inflammatory dendritic cells are key inducers of T-cell responses in human COPD lungs

【Author】

Thomas Naessens;Yannick Morias;Bart Lambrecht;Danen Cunoosamy;

【Abstract】

<正>Rationale:Dendritic cells(DCs)comprise several subtypes with different phenotypes and functional properties.During steady state,two subsets of conventional(c)DCs,c DC1 and c DC2,populate the peripheral tissues.Upon inflammation,so-called inflammatory(infl)DCs appear at the peripheral site.In this study,we investigated the functional role of this novel DC subset in human COPD lungs and their contribution to pathology.Method:Resected lungs of COPD subjects(n=3)and non-smoker(NS,n=3)and

【Keywords】

lungs;inflammation;subset;comprise;pathology;assessed;comparable;phenotype;populations;inducer;

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