Regulatory T cells promote the high expression of Lgr5 in gastric cancer cells through TGF-β1

【Author】

Xiao-Sun Liu;Xian-Ke Lin;Hai-Long Jin;Yu Hang;Ji-Ren Yu;

【Abstract】

<正>The leucine-rich repeat containing G protein-coupled receptor 5(Lgr5),as a target gene of the Wnt signaling pathway,is overexpressed in some types of human tumors and considered as one of the potential marker of cancer stem cells(CSCs).However,the interactions between Lgr5 and tumor immune micro-environment are less understood.This study explore the relationship between Lgr5 expression and

【Keywords】

understood;leucine;signaling;inhibited;marker;cultured;exogenous;inductive;likely;antagonist;

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