Dendritic cell production of the chemokine CCL17 is required for optimal Th2 induction against both helminths and allergens

【Author】

Peter Cook;Alexander Phythian-Adams;Sheila Brown;Freya Svedberg;Danen Cunoosamy;Irmgard Forster;Andrew MacDonald;

【Abstract】

<正>Dendritic cells(DCs)are essential for initiation of type-2 responses,which are important for immunity to helminth infection as well as being a major contributor to allergic disease.However,the mechanisms DCs employ to promote type-2 responses remain poorly understood.We previously identified a crucial role for Mbd2,a methyl-Cp G binding protein that links DNA methylation to repressive chromatin structure,in regulating DC gene expression and ability to initiate Th2 immunity in

【Keywords】

immunity;allergic;methylation;understood;initiate;links;contributor;poorly;regulating;chemokine;

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