Methyltransferase Ash1l controls inflammation by suppressing TLR-triggered macrophage activation and promoting TGF-induced iTreg cell generation

【Author】

Meng Xia;Juan Liu;Shuxun Liu;Kun Chen;Hongyu Lin;Yiquan Xue;Minghong Jiang;Xiaoqing Xu;Xuetao Cao;

【Abstract】

<正>Histone modifications play important roles in multiple physiological processes by regulating gene expression.However,the roles of histone modifications in immunity remain poorly understood.With a screening test by knocking down the 14kinds of enzymes involved in H3K4 methylation in mouse macrophages,we found that Ash1l,a H3K4 methyltransferase,suppresses IL-6 and TNF production in

【Keywords】

macrophages;triggered;methylation;immunity;physiological;inflammation;understood;suppressing;screening;poorly;

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