Preferential transmission of HIV-1 founder viruses by vaginal myeloid dendritic cells

【Author】

Ruizhong Shen;John Kappes;Holly Richter;Phillip Smith;

【Abstract】

<正>HIV-1 transmission is characterized by the selective acquisition and expansion of transmitted/founder(T/F)R5 viruses during acute infection.However,the mechanism(s)for selecting a single T/F virus from the numerous R5 variants inoculated onto the recipient mucosa and the role of virus-mucosal cell interaction in the selective transmission have yet to be defined.We report here that primary

【Keywords】

founder;vaginal;myeloid;recipient;mucosa;numerous;selecting;transmitted;inoculated;lamina;

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