Anti-CD24 antibody ameliorates anti-HBV immunity during interferon a therapy

【Author】

Binqing Fu;Dongyao Wang;Jiabin Li;Rui Sun;Zhigang Tian;Haiming Wei;

【Abstract】

<正>Type I interferons are widely used for antiviral therapy,yet achieve disappointing effects towards chronic HBV infection.Here we investigate whether the balance between immunosuppression and immunostimulation is tipped during Peg IFNa therapy.We demonstrated that,persistent Peg IFNa therapy induced IFNAR1expressions on CD24hiBreg cells and launched a CD24hiBreg-centered immunosuppressive program,including a negative impact on the formation of

【Keywords】

immunity;interferon;antiviral;centered;persistent;prior;satisfactory;suppression;eliminate;monocyte;

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