Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

【Author】

Xiaopeng Qi;

【Abstract】

<正>Lysosomal cathepsins regulate an exquisite range of biological functions,and their deregulation is associated with inflammatory,metabolic and degenerative disease in humans.Here,we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy.Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida.Genetic deletion or pharmacological inhibition of

【Keywords】

cathepsin;deletion;Cathepsin;macrophages;defense;degenerative;intrinsic;pathogen;regulate;cytosolic;

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