Siglec1 feedback suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

【Author】

Qingliang Zheng;Jin Hou;Ye Zhou;Yingyun Yang;Bing Xie;Xuetao Cao;

【Abstract】

<正>Type I interferon(IFN)production plays pivotal roles in host antiviral innate immune response,but excessive production of type I IFN leads to the development of immunopathological conditions.The mechanisms for tightly regulating host type I IFN production are currently of great interest.Here,we found that lectin family member Siglec1 expression was upregulated by viral infection in macrophages,

【Keywords】

innate;antiviral;ubiquitin;tightly;macrophages;interferon;inducing;lectin;currently;ligase;

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