Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis

【Author】

Xiaopeng Qi;

【Abstract】

<正>Allergic asthma is a chronic inflammatory disorder of the airways that affects more than 300 million people worldwide.The pro-inflammatory cytokines IL-1a and IL-1b play essential roles in the pathogenesis of asthma.However,the mechanisms underlying the production of IL-1 cytokines in allergic asthma remain unclear.In this study,we used a mouse model of ovalbumin(OVA)–induced asthma to identify a crucial role for caspase-8 in the development of allergic airway inflammation.We

【Keywords】

asthma;caspase;pathogenesis;allergic;ovalbumin;airway;cytokines;inflammation;promoting;unclear;

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