Invariant NKT cells recruit CD103+ dendritic cells via XCL1-XCR1 axis, thereby promoting allergic airway resistance

【Author】

Yeon Duk Woo;Hye Young Kim;Doo Hyun Chung;

【Abstract】

<正>Among immune cells,dendritic cells(DC)and invariant(i)NKT cells are critically implicated in allergic asthma.However,the crosstalk between two subsets remains elusive in asthma.To address this,we investigated how these two subsets interactand exert regulatory effects on asthma.Upon intranasal inoculation of WT mice with synthetic ligand,a-galactosyl ceramide(a-Gal Cer),CD103+DCs were significantly

【Keywords】

allergic;asthma;crosstalk;invariant;airway;elusive;implicated;recruit;thereby;promoting;

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