Grb2 is important for T-cell development, T-helper cell differentiation and induction of EAE

【Author】

Daniel Radtke;Sonja M.Lachner;Nadine Szumilas;Lena Sandrock;Jochen Ackermann;Lars Nitsc hke;Elisabeth Zinser;

【Abstract】

<正>The small adaptor protein Growth factor receptor-bound protein 2(Grb2)modulates and integrates signals from receptors on cellular surfaces in inner signalling pathways.In murine T cells,Grb2 is crucial for amplification of TCR signalling.T cell specific Grb2fl/fl Lckcretg Grb2 deficient mice show reduced T cell numbers due to impaired negative and positive selection.In this study,we found

【Keywords】

impaired;amplification;helper;deficient;induction;populations;explained;murine;differentiate;stimulation;

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