Cell type specific expression and induction of IL-33 m RNA and protein

【Author】

Jürgen Brück;Alexandra Schl?gl;Julia Holstein;Katharina Meier;Birgit fehrenbacher;Kamran Ghoreschi;Amir S.Yazdi;

【Abstract】

<正>Key mediators of innate immunity during skin inflammation are cytokines of the interleukin-1(IL-1)family.While IL-1βand IL-18 are well characterized and are activated via inflammasome activation,the activation of IL-33 is still cryptic and in contrast,IL-33 is claimed to be inactivated by caspases.Recent data suggest that IL-33 acts as an alarm or danger signal and is released after cell damage.Besides binding to its specific receptor ST2,IL-33 can be present in the nucleus and in the

【Keywords】

caspases;innate;interleukin;immunity;claimed;alarm;nucleus;danger;inflammation;cytokines;

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