High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis

【Author】

Lu Cheng;Huimin Jin;Yetao Qiang;Shuiyun Wu;Cheng Yan;Mutian Y an;Tengfei Xiao;Nannan Yan;Sheng Xia;

【Abstract】

<正>Inflammatory bowel disease(IBD)is a multi-factorial complex disorder,which is characterized with intestinal chronic inflammation of gastrointestinal tract.Epidemiological studies have shown that fat rich western diet contributes to the high incidence of IBD by promoting the change of commensal flora composition and metabolism.But,the exact mechanisms for fatty diet in gut inflammation are not well demonstrated.In this study,we found that high fat diet(HFD)promoted

【Keywords】

homeostasis;inflammation;exact;factorial;metabolism;mucosal;dextran;promoting;incidence;promoted;

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