Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway

【Author】

Yan Wang;Jingxia Zhao;Tingting Di;Mingxing Wang;Zhitong Ruan;Lu Zhang;Yujiao Meng;Xiangjiang Xie;Yan Lin;Xin Liu;Ning Wang;Ping Li;

【Abstract】

<正>Objective:Lithospermum whose key component isβ,β-dimethylacryloyl alkannin(DMA)possesses good efficacy for treating psoriasis.DMA can inhibit activated dendritic cells(DCs),but the mechanism was unknown.The aim of this study was to explore the influence of DMA on psoriasis activated DCs by the TLR7/8pathway.Methods:BALB/c mice were established asa model for psoriasis-like skin lesions.2.5 mg/kg DMAwas intragastrically administered.Thighbone and tibiabone marrow

【Keywords】

treating;inhibit;cytometry;secretion;spleen;secreted;intracellular;induction;RNA;cytokines;

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