Characterisation of murine bone-marrow derived tolerogenic dendritic cells

【Author】

Maria Christofi;Izabela P.Klaska;Lucia Kuffová;John V.Forrester;

【Abstract】

<正>Recent studies(Helft et al.,2015)showed that culture of murine bone marrow cells in GM-CSF generates a low yield of CD11c~+MHCII~+CD135~+bone marrow-derived dendritic cells(BMDCs)and that the greater population of cells in the culture are CD115~+monocyte/macrophage myeloid cells.Additionally,the CD135~+BMDC population were MHCIIhi.We wished to generate tolerogenic MHCIIlo BMDCs(tolBMDCs)and have used a modified protocol based on culturing a predominantly

【Keywords】

predominantly;myeloid;macrophage;monocyte;murine;mature;progenitor;autoimmune;ultimate;endotoxin;

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