CISH-knockout mice resistant to DSS-induced colitis by regulation of DC-mediated mucosal immune response


Se Eun Byeon;Ezra Lee;Yideul Jeong;Yujin Park;Yong-Soo Bae;


<正>CISH is a member of the SOCS family.CISH gene mutations in humans were reported to be strongly associated with susceptibility to diverse infectious diseases.We found that CISH is significantly induced during DC development,and triggers DC differentiation from the precursor cells to become a highly immunogenic type 1polarized DCs,which are essential for preventative or therapeutic immunity against




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