Bone morphogenic protein 7(BMP7) promotes in vitro generation of high numbers of inflammatory type Langerhans-like dendritic cells

【Author】

Izabela Borek;Rene K?ffel;Julia Feichtinger;Nighat Yasmin;Corinna Krump;Madhura Modak;Gerhard Thallinger;Peter Wolf;Herbert Strobl;

【Abstract】

<正>Introduction:Several mouse models of psoriasis suggested a positive feedback loop between dendritic cells(DCs)and keratinocytes.Enlarged epidermis populated with abnormal Langerhans cells(LCs)is the hallmark of this disease.Epithelial factors imprinting inflammatory LCs phenotype are under investigation and the role of LCs in psoriasis remains controversial.

【Keywords】

Langerhans;imprinting;phenotype;abnormal;controversial;profiling;cytokine;ultrastructure;inflammation;Electron;

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