Functions of dendritic cells in 5-Aza-2'-deoxycytidine pretreated experimental autoimmune encephalomyelitis

【Author】

Chia-Bin Chang;Shu-Fen Wu;

【Abstract】

<正>Autoimmune diseases are due to the failure of immune tolerance triggered by environmental factors in genetically susceptible individuals.Environmental factors through epigenetic mechanism can modify immune expression without change the genetic code.In our recent data we using low dose of 5-aza-2-deoxycytidine(5-Aza),an inhibitor of DNMT,we found that 5-Aza applied peripherally could suppress the

【Keywords】

deoxycytidine;autoimmune;peripherally;suppress;triggered;inhibited;susceptible;modify;epigenetic;effector;

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