CD1c+ dendritic cell origin of Langerhans cell histiocytosis and reconstituting Langerhans cells

【Author】

Paul Milne;Venetia Bigley;Kaibo Duan;Antoine Neel;Muzlifah Haniffa;Michael Podinger;Florent Ginhoux;Carl Allen;Matthew Collin;

【Abstract】

<正>Langerhans cell histiocytosis(LCH)is caused by somatic mutations activating the ERK pathway.Although LCH cells are LC-like,the identity of LCH precursors remains unresolved.BRAFV600E,a frequently occurring mutation in LCH,allows lineage-mapping of LCH precursors.BRAFV600E was detected(mean+/-SE%)in HSC(0.5+/-0.1%),CMP(8.6+/-3.9%),GMP(1.0+/-0.4%),CD14+monocytes(4.1+/-2.8%),

【Keywords】

histiocytosis;Langerhans;activating;somatic;mutation;lineage;clone;granules;hematopoietic;neoplastic;

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