TSLP in tonsillar follicular dendritic cells correlates with IgA production by promoting tonsillar IgA class switching in IgA nephropathy

【Author】

Hongxue Meng;Huining Li;Yao Fu;Jing He;Takanobu Kabasawa;Hiroya Ohtake;Rintaro Ohe;Nobuo Ohta;Seiji Kakehata;Mitsunori Yamakawa;Jingshu Geng;

【Abstract】

<正>IgA nephropathy(IgAN)is characterized by high serum IgA levels and IgA deposition in the renal mesangium.Previous studies suggest that elevated serum IgA partly originates from the tonsils.Here,we investigated the mechanisms of IgA production in the tonsils of patients with IgAN.Immunohistochemistry revealed that the number and relative percentage of IgA-bearing cells were significantly increased in

【Keywords】

follicular;switching;promoting;elevated;partly;activating;deaminase;APRIL;BAFF;pathogenesis;

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