C5a/C5aR pathway initiates the psoriasis skin inflammation by potentiating plasmacytoid dendritic cell function

【Author】

Quanyou Zheng;Shenju Liang;Leyu Yan;Guiqing Li;Guilian Xu;Keqin Zhang;

【Abstract】

<正>Objective:Psoriasis is one of the most common chronic inflammatory skin diseases,affects~2%of the population all over the world.Lacking understanding of psoriasis pathogenesis has in essence hindered efficient clinic treatment.Increasing evidence indicate that the complement system performs an essential role in the developmentof psoriasis.Herein,we investigated the effect of C5a/C5a R pathway in the pathogenesis of psoriasis and explored the underlying mechanism utilizing the IMQ

【Keywords】

pathogenesis;essence;inflammation;complement;utilizing;clinic;affects;underlying;infiltration;cytokines;

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