RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease

【Author】

Honglin Wang;

【Abstract】

<正>Retinoic acid inducible-gene I(RIG-I)functions as one of the major sensors of RNA viruses.DDX58,which encodes the RIG-I protein has been newly identified as a susceptibility gene in psoriasis.Here,we show that the activation of RIG-I by5’ppp-ds RNA,its synthetic ligand,directly causes the production of IL-23 and

【Keywords】

antiviral;interleukin;susceptibility;signaling;RNA;innate;phenotype;injections;confined;failed;

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