Transcriptional targeting of mature DCs by the newly characterized human CD83 promoter – prospects for new in vivo DC vaccination strategies

【Author】

Ilka Knippertz;Marcello F.Stein;Thomas H.Winkler;Andrea Deinzer;Dirk M.Nettelbeck;Michael Stürzl;Robert K.Slany;Thomas Werner;Alexander Steinkasserer;

【Abstract】

<正>One of the biggest challenges facing cancer therapy today is the development of new cell type-specific and personalized treatment strategies,including DC-based cancer vaccines.Since the CD83 molecule is only expressed by immunogenic mature DCs(m DCs)but not by immature,tolerogenic DCs(i DCs),the CD83 promoter represents an ideal tool for transcriptional in vivo targeting of m DCs directly in

【Keywords】

promoter;mature;targeting;vaccination;vaccines;today;challenges;facing;encoding;reporter;

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