Insufficient dendritic cell activation limits the efficacy of therapeutic DNA vaccination into the epidermis

【Author】

Nikolina Babala;Astrid Bovens;Jannie Borst;Adriaan Bins;

【Abstract】

<正>Therapeutic vaccination against cancer aims to elicit a tumor-eradicating cytotoxic T lymphocyte response.This approach is promising but not yet sufficiently effective.We are optimizing a strategy of DNA vaccination into the epidermis.In this approach,vaccine protein is produced in keratinocytes and delivered to the proximal draining lymph node(DLN),where T cell priming occurs.To investigate the

【Keywords】

vaccination;proximal;lymphocyte;cytotoxic;elicit;vaccine;sufficiently;DNA;delivered;limits;

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