The Increase of Transmermbrane TNFα expression leads to the restoration of altered antitumor cytotoxicity of monocyte-derived dendritic cells

【Author】

Tamara Tyrinova;Olga Leplina;Sergey Mishinov;Marina Tikhonova;Anton K alinovskiy;Sergey Chernov;Vyacheslav Stupak;Alexander Ostanin;Elena Chernykh;

【Abstract】

<正>Besides the antigen-presenting function,dendritic cells(DCs)possess ability to lyse tumor cells.DC cytotoxic activity can be stimulated greatly by type I IFN.Monocyte-derived DCs of high-grade glioma patients generated in the presence of IFNα(IFN-DCs)are characterized by defective tumoricidal activity against TNFα-sensitive tumor cells.The aim of the present study was to investigate mechanisms underlying of the impairment of DC cytotoxic activity and the

【Keywords】

cytotoxic;restoration;impairment;altered;glioma;antitumor;stimulated;defective;monocyte;possibility;

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