TLR-activated pDCs inhibit the growth of breast cancer cells


Jing Wu;Shuang Li;Shan Zhu;Yuan Qiao;Yong-Jun Liu;Jingtao Chen;


<正>Cancer immunotherapy pull accumulative attentions.Plasmacytoid dendritic cells(p DCs)are key regulators at the interface of innate and adaptive immunity.Anincreasing number of reports have associated p DCs with tumor immunity.Imiquimod or Cp G trigger a large amount type I interferons(IFNs)through Toll-like receptor(TLR)7 or TLR9 in p DCs,hence active these cells.Recent studies have established that activation of p DCs could kill melanoma cells thus inhibited tumor




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