Anti-Human CD83 imunosuppression targets activated DC and a unique CD83+ T cell population

【Author】

Xinsheng Ju;Pablo Silveira;Wei-Hsun Hsu;Zehra Elgundi;Renz Alingcastre;Nirupama Verma;Phillip Fromm;Jennifer Hsu;Christian Bryant;Zid uo Li;Fiona Kupresanin;Tsun-Ho Lo;Helen Mc Guire;Barbara Fazekas de St Groth;Stephen Larsen;John Gibson;Kenneth Bradstock;Georgina Clark;Derek Hart;

【Abstract】

<正>CD83 is an important marker of activated dendritic cells(DC).We used a rabbit polyclonal anti-CD83 antibody and a human anti-human CD83 monoclonal antibody,3C12C,to deplete activated DC as a new approach to immunosuppression.Anti-CD83 prevented human PBMC induced graft versus host disease(GVHD)but preserved human anti-viral and anti-leukaemic responses after transplantation into

【Keywords】

polyclonal;preserved;graft;GVHD;monoclonal;rabbit;versus;transplant;marker;hematopoietic;

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