IL-33 inhibits the differentiation and immunosuppressive activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

【Author】

Hui Xuan Lim;Seulah Choi;Tae Sung Kim;

【Abstract】

<正>Myeloid-derived suppressor cells(MDSCs)contribute to tumor-mediated immune escape by suppressing antitumor immune responses.IL-33 is capable of regulating various immune cell populations;however,the effects of IL-33 on the differentiation of MDSCs have not been well characterized.In this study,weevaluated the effects of IL-33 on MDSCs and found that IL-33 significantly reduced the differentiation of Lineage negative bone marrow progenitor cells into

【Keywords】

suppressor;progenitor;myeloid;suppressing;regulating;antitumor;populations;capable;escape;administration;

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